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The first asymmetric total syntheses of the antiviral natural products (+)-sattabacin and (+)-4-hydroxysattabacin are reported. Progress toward the asymmetric total synthesis of (+)-sattazolin is also reported. These total syntheses are remarkably concise and were completed without the use of protecting groups. Unambiguous assignment of the absolute configuration of both (+)-sattabacin and (+)-4-hydroxysattabacin was also accomplished. The syntheses...